Sildenafil Definition and Principles of Action
A pharmacist would generally define Sildenafil citrate as a medication which combats erectile dysfunction – although it does have a number of other uses.
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However, before taking any erectile dysfunction products you should familiarize yourself with as much information about the drug as you can – in this article we’ll address how long it lasts in the body and how long does it take to work alongside the mechanism of action and any potential risks.
What Is Sildenafil
A pharmacist would generally define Sildenafil citrate as a medication which combats erectile dysfunction – although it does have a number of other uses. The most common trade name for Sildenafil is Viagra, the nomenclature under which Pfizer originally marketed the drug. It belongs to a group of medicines known as phosphodiesterase type-5 inhibitors (or PDE-5 inhibitors for short). There are a number of popular PDE-5 inhibitors on the market, but Sildenafil is by and large the most popular treatment choice, with millions of regular users across the world.
The fact that Sildenafil works as a solution to ED was something of an unexpected discovery – medical researchers trialing a new angina medication found that one of the side effects for men was the ability to get and maintain an erection when they previously struggled to. This accidental discovery was to change the world, and Sildenafil has been used for combating impotence ever since.
Perhaps the most convenient aspect of the drug is that a Sildenafil tab only needs to be taken on and as-and-when basis. With a shelf life of approximately 2 years, the medication can simply be purchased and kept at home, ready for use when needed.
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Mechanism of Action
Most men are curious when it comes to the uses of Sildenafil; how to take it, what does it do and so on are some of the most common queries regarding the drug, alongside what to do if the medication is not working, how long it lasts in your system, and whether it’s safe.
Some people are under the misconception that the main action of Sildenafil is to instantly cause an erection. On the contrary, the penis will not simply become erect of its own volition after taking a tablet. In order to gain an understanding of how medications like Sildenafil work, it’s important to understand the physiology of getting an erection.
When a man becomes stimulated sexually, this causes the body to release a chemical compound known as nitric oxide. This enzyme in turn produces another chemical known as cGMP (cyclic guanosine monophosphate). cGMP relaxes the muscle cells of the penis, resulting in dilation which allows blood to flow into the organ much more efficiently. When the erectile tissue has been engorged with blood, an erection happens.
Sildenafil reacts to the physical symptoms of ED, which means that it doesn’t affect the release of nitric oxide into the body. This only happens when a man becomes aroused.
The primary use of Sildenafil is in the treatment of men who have issues when it comes to achieving and maintaining an erection. However, Sildenafil can be used to help alleviate a number of symptoms from other illnesses, and is an effective treatment for pulmonary hypertension – a condition where patients suffer from high blood pressure inside the lungs.
Of course, most people who are asked “what is the use of Sildenafil” will say that it increases the potential for sexual performance, although its properties for widening blood vessels in the lungs mean it can also be used, in men and women, to help increase exercise capacity, making it a useful drug for those rehabilitating and getting back into exercise after an illness which has left them with a sedentary lifestyle.
How Long It Lasts In Your System?
Before committing to a purchase, most men like to know how to use Sildenafil safely, and how long it will last in their system. Because each of us is different, there’s no exact science in terms of working out precisely how long the drug will last, but physiological factors such as weight, height, and age are all good indications for working out the length of time the drug will remain in the system for.
Sildenafil has quite a short half-life when compared to other PDE-5 inhibitors, which means it gets out of your system relatively quickly. Other drugs of the same type can last for up to 36 hours, which is why so many people prefer Sildenafil – particularly because another dose can be taken straight after the effects wear off, making it a convenient choice of drug.
Circumstantial factors also play a role in the efficacy and life of Sildenafil in the blood stream. For example, the amount of food a person has eaten over the course of a day will play a large part in determining how quickly the drug will begin to work and how long it lasts for. By and large, most men report that Sildenafil gets to work within an hour of ingesting, and the effects can be felt for anything up to four hours afterward.
This doesn’t mean that taking a pill will cause a four-hour erection though. It simply means that during this four-hour period you will have the ability to achieve and maintain an erection as and when you desire. It is also worth noting that the drug works better on an empty stomach. For best results, it should be taken at least half an hour before any sexual activity takes place.
How to Take Sildenafil Safely
In terms of dosage, it is advisable to discuss with your doctor for instructions before self-administering a dose. Healthier men in younger age brackets generally do not need as strong a dose as older males, but as a general starting point 50mg is the preferred option as recommended by medical professionals. If the medication does not cause the required effects at a 50mg dose, incrementally higher doses are recommended until the desired effects are achieved.
In certain circumstances, Sildenafil and other PDE-5 inhibitors should be avoided – most notably when the patient is currently taking medications which strongly interact with the compound. Your doctor should be able to provide you with any indications as to why you should avoid Sildenafil.
Although combining Sildenafil with some medications will only result in very mild Viagra side effects, some medications can cause fatal reactions. Those who are currently taking medication for heart problems or chest pain are advised to avoid Sildenafil completely. If you are taking any of the following drugs, you should be aware that the following side effects may occur:
- Clarithromycin may cause priapism.
- Amoxycillin causes priapism.
- Erythromycin causes increased effects of Sildenafil.
- Isosorbide causes blood pressure to fall.
- Amyl Nitrite causes blood pressure to fall.
Where Can I Buy Sildenafil Without Prescription
The real beauty of connectivity in the 21st century is that it is now possible to buy medicines online for marginally less than they would cost in traditional walk-in drug stores. It’s a little-known fact that many of the generic drugs manufactured in countries like India are actually created for consumption in the US and Europe. By purchasing direct online, you are essentially cutting out a middleman and making a huge saving.
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