Avanafil: dosages, side effects, interaction | BuyEDTabs

Avanafil: Dosages, Side Effects, Interaction

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Avanafil: Dosages, Side Effects, Interaction

Less known analog of popular drugs against erectile dysfunction Stendra is just as good as them. The remedy contains the active ingredient avanafil which helps men get a stable erection whenever they want and feel more confident in bed with their partner. The main benefit: it works even quicker than Cialis, kicking in during 15 minutes from intake.

Even though the majority of men are uncomfortable with their sex lives from time to time, the first symptoms of erectile dysfunction (further referred to as ED) are not a prison sentence. Still, with due care and attention to your men’s health and with the support of specially designed tablets, you can keep such issues to a minimum.

There are a number of distinguished ED medications on the market: Viagra (sildenafil), Levitra (vardenafil), and Cialis (tadalafil) are the most popular and used ones. Avanafil is not as well-known as them, but it isn’t less effective. In some cases, it works even better than those drugs and that’s why may be more suitable for a particular person.

What Is Avanafil?

Avanafil is a PDE5 inhibitor (here and below – phosphodiesterase type 5 inhibitor) widely used for erectile dysfunction treatment. It is a relatively new remedy, the production of which was started only in 2013 by the American pharmaceutical company Vivus Inc.

It has a pretty similar mechanism of action to other PDE5 inhibitors: blood flow to the penile chambers is increasing due to the nitric oxide release and smooth muscles of cavernous bodies’ relaxation. Those substances maintain an erection and help men to improve their performance during intercourse. Avanafil works only in the case of sexual arousal, so it will not cause an erection in everyday life without any reason.
Avanafil: dosages, side effects, interaction

Available Avanafil Brands

This ingredient is an integral part of Stendra and Spedra medications manufactured by Vivus. Stendra is common in the American market, while Spedra is promoted by the company’s partner, Menarini Group, in 40 European countries, Australia and New Zealand.

Apart from Vivus, there is more than one manufacturer in India which produces so-called generic Stendra. At first sight, such products compare favorably with brand ones because of their lower price. Here you have no guarantee of the high-grade quality – unoriginal drugs may be useless or even harmful to human health. The customer indeed pays a bit more for the well-established brands, but he will be sure of the 100% remedy’s efficiency.

Dosages and Forms

AvanafilAvanafil is available in both online and land-based pharmacies in three forms:

  • 50 mg tablets;
  • 100 mg tablets;
  • 200 mg tablets.

The average starting dose is 100 mg. It may be adjusted in accordance with the individual differences of each man. If you don’t feel much effect or your tolerability has risen, you may increase the dosage up to 200 mg.

Decrease the drug serving to 50 mg if you are taking alpha-blockers or other medications which don’t interact very well with avanafil. Also, it may be reduced due to particular health conditions. The dosage below 50 mg doesn’t provide a benefit, so there is no sense to take less.

Can I Take Avanafil?

Now that you figured out what is avanafil, you should ensure that this component is safe for your body. The one crucial restriction is as follows: Stendra is prohibited for people who are allergic to its components. A man should also consult a doctor before using if he has:

  • heart malfunctions or recent surgery, stroke or another serious problem with the cardiovascular system;
  • fluctuations of blood pressure or permanently high or low pressure;
  • angina and breathing issues;
  • liver and kidney diseases;
  • various blood disorders;
  • serious vision impairment;
  • a stomach ulcer;
  • penis deformity.

Usually, avanafil is well-tolerated, so people without serious health problems may take it safely. It is worth noting that Stendra and Spedra are not intended for women and their impact on pregnant hasn’t been studied yet.

How to Take Avanafil Pills?

ErectionIf you discussed the feasibility of the drug’s usage with your doctor and he or she has approved this solution, go ahead and follow your prescription. Take the serving specified there and don’t change your dose drastically without contacting a doctor.

Avanafil pills are usually taken with a small amount of liquid; the number of tablets depends on the medicine’s form and dosage. The manufacturer states that the time of the last meal doesn’t matter but experts recommend using the drug on an empty stomach. This way, the substance has better solubility, and the body absorbs it quicker. The erection will be forthcoming.

It is preferable to take avanafil in advance: at least 30-60 minutes before sex. You will achieve an erection when you feel sexual arousal – an indispensable condition for a success. At the end of intercourse, your penis will return to its regular state.

Do not take drugs containing avanafil more than once a day. Let 24 hours pass between the usages.

Side Effects

Even though Stendra is safe for a healthy person, some side effects may occur, especially at the initial stages of the treatment. The majority of them don’t require medical care and disappear after the body gets used to the medicine. However, they bring sort of discomfort, so you should be aware of what may happen after your first use and be ready for that.

The other group of possible negative reactions may be dangerous for your body; in this case, you should stop the treatment and contact your doctor.


The most widely spread unwanted effects affecting the patients are:

Those which need medical attention

Those which do not need medical attention

Blurred vision
Tinnitus Flushing
Heart rhythm disruptions Fever
Headache Sore throat
Muscle pain Stuffy nose
Feeling of warmth


These effects are very seldom, so you should worry less about them. Some men reported about such issues, so they also have to be listed:

Those which need medical attention

Those which do not need medical attention

Back, bladder, arm, jaw, genitals, chest or other body parts’ pain

Indigestion or diarrhea
Blood in the urine, pain or discomfort during urination, enuresis


Breathing difficulties or chest tightness

Sweating or shivering
Vomiting and nausea


Fatigue and weakness

Unusual drowsiness
Unexpected weight gain or loss

Muscle spasms

Increased appetite


PoisoningDo not take serving more than 200 mg per day. It may cause an overdose and you will require medical help. If you noticed symptoms of poisoning of yourself or another person, call the local Poison Control Center or an ambulance to receive emergency care.

Before the ambulance arrives, try to remove the drug surplus from the body through stomach pumping and providing the injured with a safe environment.


You may notice the enhancement of particular side effects if it is taken in combination with some food, medications, or beverages. To minimize risks, avoid the products listed above and fully enjoy your sexual experience without backfire.

Interaction of Avanafil with Food

Alcohol and grapefruit juiceDrugs containing avanafil may be used before, during, or after a meal according to the official instructions. The only product affecting the person in a negative way together with Spedra or Stendra is grapefruit. So, avoid drinking grapefruit juice or eating salads, desserts, or the other dishes containing it, as it can cause an adverse effect.

All other products are acceptable while taking avanafil medication. However, the drug takes effect quicker if you refrain from food a couple hours before using it.

Avanafil and Alcohol Drinks

It is not recommended to mix alcohol and avanafil. As you may know, alcohol in high dosages prevents erection even in young men. Another threat of this combination is an increase of common side effect probability. Stendra + alcohol is not dangerous, though. Therefore, it is your choice whether to drink such beverages before or after taking avanafil, but limit consumption to a couple glasses of beer or wine and no more.

Other Drugs and Avanafil

Avanafil is prohibited to use with riociguat (Adempas) and nitrates like nitroglycerin (Nitromist, Nitro-Dur, Minitran), isosorbide dinitrate (Dilatrate-SR, Isordil), isosorbide mononitrate (Monoket) etc. Such medications are often taken for cardiovascular diseases treatment. Also, they may be supplied in various forms including pills, sprays, pastes, and so on. If you don’t know whether your medicines contain nitrates, ask your doctor. Do not take Spedra together with these drugs, as it is unsafe for your health.

Some recreational drugs also contain nitrates. Such substances as amyl nitrate and butyl nitrate are known better for their street name “poppers” and are not compatible with avanafil.

Do not combine avanafil with other PDE5 inhibitors such as sildenafil, tadalafil, or vardenafil. The most widespread brand names for them are Viagra, Cialis, Levitra, Staxyn, Revatio, and Adcirca.

Before starting the treatment, inform your doctor about all medicines you take.

AntibioticsHere is the list of those which require special attention:

  • antibiotics (clarithromycin, erythromycin, telithromycin);
  • immune supportive medicines used in case of HIV or AIDS (atazanavir, indinavir, saquinavir);
  • antifungal drugs (ketoconazole, itraconazole);
  • remedies against hepatitis C (boceprevir, telaprevir);
  • alpha blockers (alfuzosin, prazosin, terazosin);
  • medications for high blood pressure (nefazodone, verapamil).

Take into account that even some dietary supplements, minerals, and vitamins may influence avanafil’s effect, so be careful while using those together with the remedy.

Other Avanafil Alternatives

The list of similar substances to avanafil includes sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and dapoxetine (Priligy). The first established brand name among those is Viagra by the Pfizer company. The other two emerged later and are slightly different from it. Let’s compare those medicines with avanafil.

Avanafil Versus Viagra Sildenafil

Many people make their choice based on the question “How long does it last” applicable to each of the ED drugs. To compare avanafil vs sildenafil, the first one has indisputable advantages: it lasts 1-2 hours longer (6 hours of Stendra’s duration against of 4-5 Viagra’s) and kicks in quicker (15-20 minutes vs 30 minutes respectively). Food doesn’t influence avanafil’s effect, so it can be taken with the meal, while sildenafil’s effect may be delayed if used together with food.

The side effects inherent to these drugs are pretty similar. However, Stendra commonly causes nasal congestion and runny nose, while Viagra more often becomes a reason for indigestion.

Avanafil vs Cialis

CialisCialis is famous for its super durability due to its longer half-life. In comparison of avanafil vs Cialis Stendra is losing in effect’s lasting: it works for 6 hours on the average while Cialis lasts up to 36 hours. As for kicking in, the drugs are almost equal and both are resistant to food.

The most typical side effects for Stendra are facial flushing, headache, and stuffy nose. For Cialis – headache and indigestion. Both drugs are cheaper than Viagra, which could be a major cause for purchasing it.

Users’ Reviews

Apart from scientific studies proving the efficiency of the drug, it is important to know what real people say about avanafil’s action. The best way to express your impressions is to write a customer review.

The majority of users are satisfied with both Stendra and Spedra and confirm its efficiency. They say the drug helped them to return their virility back by maintaining stable and durable erection within intercourse. Some customers notice avanafil suits them even better than similar medicines. There are few reports about minor side effects, but most men feel good after taking Stendra.

Buy Avanafil OTC Online

Online pharmacyIf you stumble upon an ED issue for the first time, you may wonder where to buy such remedies over the counter. Stendra, Spedra, and other drugs such as Viagra, Cialis, and Levitra are available in online pharmacies without a prescription. BuyEDTab is one of them and has some benefits over the others.

Why choose us? We provide fast and safe shipping throughout the USA within 10-18 days. An express delivery option speeds up the process, and you can receive the package within 7-10 days after ordering. Track our special offers: you can get 35% discount while using bitcoins while paying.