Tadalafil side effects and interactions | BuyEDTabs

Tadalafil Side Effects and Interactions

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Tadalafil Side Effects and Interactions

Most men are able to use Tadalafil without any uncomfortable side effects. Among those who do experience an adverse reaction, most of the side effects are non-serious.

Tadalafil, also known as Cialis or “the weekend pill”: it’s an erectile dysfunction medication with a long-lasting effect that has made it extremely popular. But since you know this pharmaceutical is serious business, you want to get more information before committing to it, and one of your concerns is whether it will be right for you, and how you’ll know if it isn’t. What’s the worst that could happen? What should you do when using it, and what should you avoid?

What Are Side Effects of Tadalafil?

Most men are able to use Tadalafil without any uncomfortable side effects. Among those who do experience an adverse reaction, most of the side effects are non-serious and might indicate that you should try another ED drug.
There are also extremely rare side effects, but few of these are cause for medical concern. It’s up to you to decide whether you should continue with the medication when you experience non-threatening side effects, or whether you’d like to try another PDE5 inhibitor such as Sildenafil Citrate (Viagra).

In very rare cases, men experience side effects that will require medical attention at worst, or immediate discontinuation of the drug. No doctor can predict these, but it’s important for you to be aware of them, since the motivation to enjoy a revitalized sex-life may cause you to take risks, particularly if you are unaware of how serious your reaction to the drug may be.

Another important consideration relates to drug interactions with medications you may already be using. Certain interactions with other medications can be dangerous, and although we will try to cover these in this article, it is wisest to consult a doctor if you use other prescription medications on a regular basis.


Non-serious, but nevertheless relatively common side effects include:

  • heartburn;
  • wind;
  • indigestion;
  • upset stomach;
  • headache.

If you experience any of these symptoms, you are in the minority, but you have no cause for concern. If these side effects outweigh the benefits of Tadalafil, simply discontinue use.

There are NO serious common side effects. If that were the case, it is likely that Tadalafil would not have been accepted as a treatment for erectile dysfunction in the first place.

Slightly less common side effects include:

  • nosebleeds;
  • generalized aches and pains;
  • feeling itchy, numb or tingly;
  • tired feeling eyes;
  • a burning sensation in chest or stomach;
  • blocked or runny nose;
  • difficulty in swallowing;
  • constant thirst;
  • flushed face or feverish feeling concentrated above the upper chest area;
  • rough voice;
  • an erection that feels bigger than normal;
  • feeling shaky;
  • pain in the extremities;
  • sore throat;
  • red eyes or watery eyes;
  • vertigo;
  • sleepiness;
  • inability to sleep;
  • puffy face;
  • tummy ache;
  • rough voice.

None of these effects warrants medical attention. If they are too uncomfortable, Tadalafil is not for you.


One of the rare, non-serious side effects of Tadalafil is that colors appear different after use. Other rare side effects that are not cause of medical concern include:

  • achy arms or leg pain;
  • pain in the jaw (as if you had been clenching it for a prolonged period);
  • pain and tightness in the chest;
  • shivers;
  • sweating;
  • feelings of mental confusion;
  • feeling faint (and even fainting);
  • heart arrhythmia (only serious if you have an existing cardiac condition);
  • anxiety or feeling “jumpy”;
  • hearing a pounding noise;
  • vomiting.

You should definitely get help if you experience the rare side effect of priapism (an erection that won’t go away and that is painful). If at any point you are concerned, call your doctor or emergency services. Be open about using Tadalafil, and allow them to evaluate your condition.

Side effects that have been reported but that have not been evaluated include itchiness, bumps or a skin rash. These are not serious but could indicate the need for a change in your choice of ED drug as you may be allergic to Tadalafil.
Tadalafil side effects and interactions

Anything Else I Should Know About?

In case you’re wondering how common “common” side effects are, we’re looking at 1-10% of men. Rare side effects affect 0.1%.

Take care how you use Tadalafil in conjunction with other drugs. If you experience extreme discomfort, discontinue use immediately. This should be enough to allow your symptoms to disappear. Although Tadalafil had been extensively tested and is recognized as a generally “safe” drug, not everyone is comfortable with it. If it doesn’t work well for you, consider an alternative.

Reducing Chance of Side Effects

As we have seen, being cautious about using Tadalafil with other drugs, and drinking moderately when using the drug will limit your chance of experiencing side effects. You should also remember that the higher the dose, the greater the chance of experiencing them.

Start with a lower dose and monitor for efficacy and side effects. Common Tadalafil dosages used from lowest to highest are: 5mg, 10mg, 20mg, 30mg, 40mg and 60mg.

Remember that Tadalafil effects last for a few days after using the medication, and continue to drink only moderately, avoiding other drugs or supplements that may result in an interaction.

Signs You May Have to Discontinue Cialis

Symptom Reason
Dizziness Low blood pressure
Heart arrhythmia or chest pain You may have an undiagnosed heart condition
Skin rash or hives, swelling, difficulty breathing You may have an allergy that can progress to more serious symptoms. See your doctor.
Leg or back pain The diuretic effect of Cialis is believed to be the cause of pain. If severe, discontinue use.
Priapism (an erection that is painful and won’t go away) Tadalafil is working rather too well for you. See a doctor as soon as possible to avoid permanent damage.

Long-Term Effects

So far, no adverse long-term effects of Tadalafil use have been identified. However, certain studies indicate that using erectile dysfunction drugs daily for several months may actually cure erectile dysfunction. When using Tadalafil daily, use the 5mg dose.

Tadalafil Interactions

Health conditions that could preclude Tadalafil use include heart disease, liver disease or kidney problems. Several other illnesses have moderate interactions with the drug. If you have an existing health condition, you should consult your physician to discover whether Tadalafil is a safe choice.

This said, Tadalafil is rarely associated with any adverse effects, and is well-tolerated by the vast majority of the men who use it.

With Food

You can use Tadalafil on an empty stomach or you can take it with food. In addition, you should avoid liquid refreshment in the form of grapefruit juice, since it can increase your risk of experiencing side effects. Many men specifically choose Tadalafil because its efficacy is less likely to be reduced when taken with food. Other ED drugs will work less well when you eat shortly before or after use.

With Alcohol

You should drink alcohol moderately when using Tadalafil since the combination of alcohol and Tadalafil can cause your blood pressure to drop, resulting in dizziness or even fainting. This effect is usually uncomfortable and worrying rather than dangerous, but you should nevertheless be cautious as in certain circumstances the interaction can be serious. However, if you would like to enjoy a glass or two of wine, or no more than two or three alcoholic drinks, you should not experience any unpleasant or uncomfortable effects.

With Xanax

If you have been experiencing extreme anxiety regarding sex because of your erectile dysfunction, doctors sometimes prescribe Xanax to be used in combination with Cialis (Tadalafil). For premature ejaculation (PE), Xanax can also delay, or even prevent ejaculation, so it is sometimes combined with Cialis for this reason.

However, you should remember that Xanax can be addictive, and if you do not suffer from sexual anxiety or PE, you should not use it, or only use it on occasion.

With Dapoxetine

Tadalafil and Dapoxetine are also combined, sometimes even in the same tablets, for men who suffer the dual problems of erectile dysfunction and premature ejaculation. Dapoxetine is also known as Priligy, and it is the only drug that has been developed specifically for the purpose of delaying ejaculation. This combination benefits many men who suffer from sexual dysfunction.

Although Dapoxetine is widely used elsewhere in the world and has an excellent safety profile, it has not been approved by the FDA. Men in the US, therefore, have to source generic Dapoxetine from pharmaceutical companies based in India.

With Other Drugs

321 different medications interact with Tadalafil. If you regularly use medications, you should check with your doctor to get a professional opinion on whether you can safely use Tadalafil.

If you do not use medications regularly, remember to inform your doctor that you are using Tadalafil when he or she prescribes other drugs. 11 drugs have “major” interactions with Tadalafil. These span 54 different brands and generics. You should also be cautious about combining Tadalafil with supplements. Innocuous though they may seem, supplements can react with other medications, not only Tadalafil.

See Your Doctor

Tadalafil is a prescription medication. Although we have strived to provide comprehensive information, this article cannot replace personalized information from your medical practitioner. For increased safety, use Tadalafil under medical supervision. Bonus! Grab our bestseller – free Cialis sample pack!